Database 5

Slay the Spire 2 Potions Database & Timing Calculator

Every live potion, one clean lookup. Filter the full list by effect, pool, rarity, or unlock wave, then use the timing calculator to answer the only question that matters in a real run: should you drink it now, or are you still saving it for a better fight?

63Live potions

60Shared pool

0Character bundles

0Unlock waves

Use This Library

Use the potions page when bottle timing is the real decision

Good potion play is not about admiring bottle rarity. It is about spending or holding at the right node.

First read

Bottle timing matters more than bottle rarity

The useful version of a potion page is one that tells you whether the bottle should be spent now, banked for the boss, or used to make the next elite route legal. The raw effect line is only step one.

When to use it

When this page helps

Open this page when you need to decide whether a bottle is route sustain, emergency insurance, a boss hold, or immediate tempo. It is strongest when belt space, upcoming elites, and exact use windows matter more than the raw effect text.

Common misread

Most common misread

Players keep treating every good bottle like sacred boss tech. That is how they die holding tempo potions, or waste future drops because the belt was full for three floors straight.

Boundary

What this page cannot replace

This page does not script the whole act for you. Once the bottle role is clear, you still need the boss threshold page, relic page, or progression tracker to decide whether spending it now is correct.

Real use example

Use it when belt space is the real problem

A real use case is checking whether a sustain bottle should be cashed before an elite so the next drop slot stays open, then confirming the threshold on the boss HP or relic side if the call is still close.

Go deeper next

Use the narrower page once the lookup is done

Boss HP GuideUse this when the bottle decision depends on one boss or elite threshold.Relic DatabaseJump here if the bottle question is really about refill, storage, or sustain relics.Epoch TrackerCheck progression if the potion question starts with what is actually unlocked in the pool.

Maintenance Signals

Who Maintains This Page

A calculator without ownership is just a fancy guess. These signals show who maintains the tool, which live ruleset it matches, and where the responsibility boundary stops.

Maintained bySTS2 Calculator Reference + Tools Desk

Independent fan-made editors and data maintainers. This is not an official Slay the Spire 2 or Mega Crit property.

Responsible editorSTS2 Calculator Site Operator

Final site operator and responsible editor. Final contact for corrections, rights notices, and maintenance triage via shwuhen@gmail.com.

Last reviewedMarch 28, 2026

Visible copy, links, and page-level signals were checked in the latest review pass.

Patch verifiedCurrent Early Access potion pool

If a patch moves the numbers, wording, or assumptions behind this page, the page gets revised, narrowed, or rechecked again.

Applies toPotion pool lookup, unlock-wave notes, synergy references, and the timing calculator exposed on this route.

Tool pages cover the math, tables, and assumptions surfaced by the current UI on this route.

DisclaimerMixed reference page plus calculator.

Timing advice is maintained judgment layered on top of the live potion dataset. Route context and belt pressure still matter more than one generic line.

Editorial standardsRead the site-wide source boundary, patch workflow, correction path, and desk ownership rules.Patch workflowRead how the site rechecks data and editorial layers after a live update.Report stale dataUse the contact page or email the site operator when a number, rule, editorial note, or rights boundary looks wrong.

How to Read Potion Value

Potion value is not theoretical power. It is how much easier the next dangerous node becomes after you click. Keep the bottles that solve elites, bosses, or ugly draws. Spend the rest before a full belt turns future rewards into dead drops.

Jump to Timing Calculator Relic Database Card Database Boss HP Guide Epoch Tracker

Count badges on this page always show what they are counting, such as potions in a timing bucket, potions in a pool, or potions added by an unlock wave.

2 potionsRoute sustain

Carry them for pathing

Use these when the bottle changes route quality, saves a Rest, or keeps the next dangerous node clean.

32 potionsCombat spike

Spend them for tempo

These are made for the turn that wins a race, fixes a draw, or removes one enemy cycle immediately.

19 potionsBoss hold

Save the ceiling

These scale hardest when the fight is long, the matchup is specific, or the payoff is simply too large for a hallway.

10 potionsEmergency save

Keep one panic button

These are strongest when a fight is about to get away from you. They are there to stop the bleed, not look pretty.

Interactive Tool

Potion Timing Calculator

This calculator is displayed here near the top of the page, directly below the opening timing guide. Pick the bottle, describe the room, and let it push back against the usual bad habit of holding everything forever.

PotionSituationPressureBelt pressure

Lean toward usingShared pool

Entropic Brew is close to a profitable click.

Its ceiling is still ahead of you. Unless slot pressure is biting, the better payoff usually arrives in an elite, boss, or any longer fight.

Best trigger

Save it for the first elite, boss, or long fight where the extra ceiling changes the result instead of just padding a clean win.

If you wait

Overholding is the danger now. If the hard fight has arrived, keeping it for a mythical better spot is just lost tempo.

Slot pressure

One more drop can force a decision. Start ranking what actually deserves storage instead of pretending every bottle is sacred.

Potion BeltUpon pickup, gain 2 potion slots.White Beast StatuePotions always appear in combat rewards.CauldronUpon pickup, brews 5 random potions.

Potion Pool Map

The pool matters. Shared bottles are the broad baseline. Character bundles widen that baseline with three class-specific picks each, while event and token entries sit outside the ordinary reward rhythm.

60 potionsShared

Shared rotation

The broad all-class shelf. Two general unlock waves expand it with six extra bottles.

AshwaterAttack PotionBeetle JuiceBlessing of the ForgeBlock Potion

2 potionsEvent

Event-only brews

Context-driven bottles that sit outside the normal shared and character pulls.

Foul PotionGlowwater Potion

1 potionsToken

Token entry

A special token-style bottle that does not behave like a standard reward pull.

Potion-Shaped Rock

Unlock Waves

These are the seven potion unlock waves currently tied to progression. General unlocks expand the shared pool, while character lines each add a three-potion bundle.

Browse All Potions

Filter the list by effect, timing, rarity, and pool. This keeps the lookup fast when you want one answer instead of the whole shelf.

SearchEffectTimingPoolRaritySort by

Shared pool

Fruit Juice

Route sustainHealingRare

Gain 5 Max HP.

Use windowAny Time

TargetAny Player

UnlockBase pool

Max HP5

When to spend it

Spend it when it changes route quality, prevents a forced Rest, or keeps the next dangerous node from costing real HP.

What makes it worth holding

The hold value is pathing. If the route is still safe and your belt is roomy, waiting is fine. Once the next reward would bounce, that patience turns into waste.

Why it matters

Its real value is future HP saved, better route freedom, and not being forced into a weaker rest-site decision.

Potion BeltUpon pickup, gain 2 potion slots.Tiny MailboxWhenever you Rest, procure a random potion.Delicate FrondAt the start of each combat, fill all empty potion slots with random potions.

Shared pool

Blood Potion

Route sustainHealingCommon

Heal for 20% of your Max HP.

Use windowAny Time

TargetAny Player

UnlockBase pool

Heal20%

When to spend it

Spend it when it changes route quality, prevents a forced Rest, or keeps the next dangerous node from costing real HP.

What makes it worth holding

The hold value is pathing. If the route is still safe and your belt is roomy, waiting is fine. Once the next reward would bounce, that patience turns into waste.

Why it matters

Its real value is future HP saved, better route freedom, and not being forced into a weaker rest-site decision.

Potion BeltUpon pickup, gain 2 potion slots.Tiny MailboxWhenever you Rest, procure a random potion.Delicate FrondAt the start of each combat, fill all empty potion slots with random potions.

Shared pool

Ashwater

Combat spikeSpecialUncommon

Exhaust any number of cards in your Hand.

Use windowCombat Only

TargetSelf

UnlockBase pool

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Pick prompt: Choose any number of cards to Exhaust.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Bone Brew

Combat spikeSpecialUncommon

Summon 15.

Use windowCombat Only

TargetSelf

UnlockBase pool

Summon15

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Cunning Potion

Combat spikeSpecialUncommon

Add 3 Upgraded Shivs into your Hand.

Use windowCombat Only

TargetSelf

UnlockBase pool

Cards3

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Cure All

Combat spikeSpecialUncommon

Gain 1 Energy. Draw 2 cards.

Use windowCombat Only

TargetAny Player

UnlockBase pool

Energy1 Energy

Cards2

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Duplicator

Combat spikeSpecialUncommon

This turn, your next card is played an extra time.

Use windowCombat Only

TargetSelf

UnlockBase pool

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Fortifier

Combat spikeSpecialUncommon

Triple your Block.

Use windowCombat Only

TargetAny Player

UnlockBase pool

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Fysh Oil

Combat spikeBuffUncommon

Gain 1 Strength and 1 Dexterity.

Use windowCombat Only

TargetAny Player

UnlockBase pool

Strength1

Dexterity1

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

If it saves HP, removes a turn cycle, or forces lethal ahead of schedule, it already earned the slot.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Gambler's Brew

Combat spikeSpecialUncommon

Discard any number of cards, then draw that many.

Use windowCombat Only

TargetSelf

UnlockBase pool

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Pick prompt: Choose any number of cards to replace.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Heart of Iron

Combat spikeBuffUncommon

Gain 7 Plating.

Use windowCombat Only

TargetAny Player

UnlockBase pool

Plating7

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

If it saves HP, removes a turn cycle, or forces lethal ahead of schedule, it already earned the slot.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

King's Courage

Combat spikeBuffUncommon

Forge 15.

Use windowCombat Only

TargetAny Player

UnlockBase pool

Forge15

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

If it saves HP, removes a turn cycle, or forces lethal ahead of schedule, it already earned the slot.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Liquid Bronze

Combat spikeBuffUncommon

Gain 3 Thorns.

Use windowCombat Only

TargetAny Player

UnlockBase pool

Thorns3

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

If it saves HP, removes a turn cycle, or forces lethal ahead of schedule, it already earned the slot.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Powdered Demise

Combat spikeDamageUncommon

Enemy loses 9 HP at the end of each of its turns.

Use windowCombat Only

TargetAny Enemy

UnlockBase pool

End-turn loss9

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

If it saves HP, removes a turn cycle, or forces lethal ahead of schedule, it already earned the slot.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Touch of Insanity

Combat spikeSpecialUncommon

Choose a card in your Hand. It is free to play this combat.

Use windowCombat Only

TargetSelf

UnlockBase pool

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Pick prompt: Choose a card to make free.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Attack Potion

Combat spikeSpecialCommon

Choose 1 of 3 random Attack cards to add into your Hand. It's free to play this turn.

Use windowCombat Only

TargetSelf

UnlockBase pool

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Block Potion

Combat spikeBuffCommon

Gain 12 Block.

Use windowCombat Only

TargetAny Player

UnlockBase pool

Block12

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

If it saves HP, removes a turn cycle, or forces lethal ahead of schedule, it already earned the slot.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Shared pool

Colorless Potion

Combat spikeSpecialCommon

Choose 1 of 3 random Colorless cards to add into your Hand. It's free to play this turn.

Use windowCombat Only

TargetSelf

UnlockBase pool

When to spend it

Use it when it removes one enemy cycle, creates lethal, or turns a shaky turn into a clean one right now.

What makes it worth holding

These bottles age badly in a crowded belt. If the current fight is real, immediate tempo is usually worth more than a hypothetical cleaner turn later.

Why it matters

Treat it like a setup shortcut. The best turn is usually the one where it unlocks a line your hand could not produce on its own.

Potion BeltUpon pickup, gain 2 potion slots.Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.AlchemizeProcure a random potion.

Potion Synergy Notes

The strongest potion setups usually come from slot management, refill pressure, or effects that turn every click into extra output.

Capacity first

Extra slots let you hold niche answers without turning every new drop into a forced discard.

Potion BeltUpon pickup, gain 2 potion slots.White Beast StatuePotions always appear in combat rewards.Alchemical CofferUpon pickup, gain 4 potion slots filled with random potions.

Refill engines

Once the belt refills itself, potions stop being luxury storage and start becoming part of the route plan.

Tiny MailboxWhenever you Rest, procure a random potion.Delicate FrondAt the start of each combat, fill all empty potion slots with random potions.CauldronUpon pickup, brews 5 random potions.

Convert clicks into swing

The strongest potion pieces do not just store value. They turn the click into damage, tempo, or another fresh bottle.

Reptile TrinketWhenever you use a potion, gain 3 Strength this turn.Petrified ToadAt the start of each combat, procure a Potion-Shaped Rock.AlchemizeProcure a random potion.

Know the tradeoffs

Some relics reward empty slots or shut the supply off entirely. Those tradeoffs change how every bottle should be valued.

SozuGain 1 Energy at the start of each turn, but you can no longer obtain potions.Belt BuckleWhile you have no potions, you have 2 additional Dexterity.

Potion FAQ

What does the timing calculator actually weigh?

It weighs the potion's normal timing window, the current fight context, how much pressure you are under, and how close your belt is to clogging. The point is not perfect play in a vacuum. The point is cleaner live decisions.

Are character potions in the same pool as shared potions?

No. Shared potions come from the common shared pool once their general unlock waves are open. Character unlock lines add their own three-potion bundles on top of that.

When should I drink route-heal potions?

Drink them when the heal changes pathing, prevents a forced Rest, or keeps an elite line open. Drinking early for empty comfort is usually how value leaks out.

Why spend a common potion before the next elite?

Because a common potion that saves one attack cycle or one bad turn has already paid for itself. The real waste is losing the next reward because the belt stayed full for no reason.